SinEcch™ Results

SINECCH™: For Facelift, Rhinoplasty, and Cosmetic Surgery Bruising, Swelling, and for Post-Operative Discomfort Recovery

The effectiveness of SINECCH™ for swelling, bruising, and post-operative discomfort recovery is well documented by both clinical experience and physicians' testimonials. SINECCH™ has been used in many instances of post-operative facelift swelling, nose surgery (rhinoplasty) swelling, and other types of cosmetic surgery swelling. Below you will find study results as well as testimonials regarding the use and effectiveness of SINECCH™.

ASPS DATA Committee Report

In addition, in their review of the worldwide medical literature regarding the safety and efficacy of homeopathic Arnica, the experts on the American Society of Plastic Surgeons (ASPS)'s Device and Technology Assessment (DATA) Committee found 10 studies that met their standards for high-quality research.  Only two of the studies demonstrated a statistically significant reduction in bruising and swelling.  Those two studies were the only two studies that tested SINECCH™ versus placebo.  The other eight studies tested various health food store strengths of homeopathic Arnica versus placebo.  All eight of the health food store strengths of Arnica were proven to be ineffective in reducing pain, bruising, and swelling.

The dosage of homeopathic Arnica in SINECCH™ is the only product on the market that follows the guidelines for the use of homeopathic Arnica after surgery as published in the journal Plastic and Reconstructive Surgery (PRS).  The guidelines were published in a letter to the editor by Dr. David Riley, who is:

  • an MD board-certified in internal medicine
  • an expert in the use of homeopathic medicine
  • the former editor of one of the major journals in the field of alternative medicine
  • a member of the Board of Directors of the Homeopathic Pharmacopoeia of the United States, the official source for the methods of manufacture of all homeopathic medicines in the United States that is used by the FDA to regulate the production of homeopathic medicines
  • a consultant to the FDA on matters regarding homeopathic medicine


The dosage regimen utilized in SINECCH™ is the only homeopathic Arnica montana product on the market clinically proven to reduce bruising and swelling after surgery, and is the only product to follow published guidelines (in PRS) on dosage in plastic surgery.

Health food store homeopathic Arnica has been proven ineffective in eight studies.  Only SINECCH™ has been clinically proven to help with cosmetic surgery (e.g., rhinoplasty, facelift, and liposuction) bruising and swelling recovery.

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Study Results

Clinical Research Study of SINECCH™ (Homeopathic Arnica Montana) in the Reduction of Ecchymosis (Bruising) after Facelift

Reported at the Eighth International Symposium on Facial Plastic Surgery on May 5, 2002.  Presented by Dr. Brook M. Seeley, Dr. Corey Maas' Fellow at the University of California, San Francisco.  Only material presented at Dr. Seeley's talk is reproduced here.  The study was also published in the Archives of Facial Plastic Surgery, vol. 8, Jan./Feb. 2006, pages 54–59: Effect of Homeopathic Arnica montana on Bruising in Face-Lifts, by Brook M. Seeley et al.

Dr. Seeley presented his study, an institutional review board-approved, randomized, prospective, double-blind, placebo-controlled trial of the Arnica montana product SINECCH™, a programmed dosage regimen of homeopathic Arnica unique to SINECCH™, produced by Alpine Pharmaceuticals.

The goal of this study was described as twofold.  First the researchers sought to develop an objective method of quantifying the amount of post-operative bruising.  They then used this method to quantify the degree of bruising of post-operative facelift in patients given either homeopathic Arnica montana in the SINECCH™ protocol or placebo. The same surgical procedure was used for all patients.  Dr. Maas and his Fellows performed all surgeries.  All patients were women with an average age of 58.  Photos were taken on Post-op Days 1, 5, 7, and 10.  Dr. Seeley utilized a computer-imaging program to analyze all of the 29 patients' photos.  The computer calculated the area of bruising in every photo.

Overall, the placebo group had 24 percent more bruising than the SINECCH™ group.  The placebo group took 50 percent longer to recover than the SINECCH™ group.

The Results Were Highly Statistically Significant for Post-op Day 1 and Day 7.

On Post-op Day 1 the placebo group had on average 26% more square cm of bruising than did the SINECCH™ group (P<0.0053).  On Post-op Day 7, the results were 41% more square cm of bruising in the placebo group (P<0.0003).

Clinical Research Study of SINECCH™ in the Reduction of Ecchymosis and Edema in Liposuction

Reported at the Research and Innovative Technology Scientific Session of the American Society of Aesthetic Plastic Surgery (ASAPS) meeting in Las Vegas, April 29, 2002.  Presented by Dr. Michael Kulick of San Francisco.  Printed in the Abstract Book of the ASAPS Conference, pages 17–18: "Arnica Montana, Role in Reducing Bruising and Swelling: Fact or Fiction?"  Only material presented at Dr. Kulick's talk is reproduced here.

Dr. Kulick presented his study, an institutional review board-approved, randomized, prospective, double-blind, placebo-controlled trial of SINECCH™.  He noted that despite the lack of quality studies on the use of Arnica montana, Alpine Pharmaceuticals has listed numerous positive SINECCH™ testimonials from many highly regarded plastic surgeons from throughout the United States.

The goal of this study was described as an attempt to determine if the claims made for Arnica montana would stand up to the demands of a true research study.  Dr. Kulick performed all 29 liposuction surgeries himself.  The patients were all women aged 18–45.  He also took photographs of the patients from the front, rear, left side, and right side at Post-op weeks 1, 2, 3, and 4.  Independent plastic surgeons with experience in liposuction were then asked to rank the 29 patients' photo sets from most to least bruising/swelling for week 1 and similarly for Post-op weeks 2, 3, and 4 separately.  There was no statistically significant difference in the volume of fat removed.  (P>0.36)  The patients receiving Arnica were significantly younger than the treatment group. (mean age 32.6 vs. 37.9) (P<.02).  However, this was accounted for in the statistical analysis that included a linear mixed-effects model to include treatment group, post-treatment week, and the interaction of the treatment group, time, and patient age.

The Results Were Highly Statistically Significant

The P-values obtained with the data from the three independent plastic surgeons were P<0.006, P<0.003, and P<0 .0001 in favor of SINECCH™ reducing bruising and swelling.

If you'd like to learn more about the efficacy of SINECCH™ for post-operative pain reduction or post- cosmetic surgery (e.g., rhinoplasty, facelift) swelling, further information is available regarding clinical studies of SINECCH™ — please contact Alpine Pharmaceuticals if you'd like to learn more.

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